Anemia is a common problem in exotic pet patients especially in emergency cases. There causes of anemia vary, such as chronic infection, renal function disorder, liver function disorder, hemorrhage, internal bleeding, malnutrition, neoplasia, parasites, hemolysis, toxin, iatrogenic, bone marrow suppression etc. It’s the most important to find out the primary disease which causes anemia, however, not every patient can survive till the examination reveals the original problem, and it also requires time to correct the problem. Rehydrate is the first step to correct these patients, then whole blood transfusion is the easiest way to temporarily and rapidly improve the anemic patient’s status. Once the patient is stabilized, the diagnosis and treatment can be allowed to carry on. The restriction of blood transfusion in these patients is blood source and the size of the animal. How to get IV line on the patients and how to search stable blood source is also very challenging. Evaluation of the recipient and the donor with the right analysis tools and methods bases on species and the body condition. Each species requires different skills, agents and tools to anesthetize, sedate and put on IV line for constant or temporary use. Correct cross-match of recipient and donor can prevent from complications. Learning the experience from different cases will help to understand more about practical skill of blood transfusion on exotic pets.